Ureda Naturals manufactures Low Molecular Weight Chondroitin Sulfate Sodium powder in a standard 3–5 kDa grade, with customized molecular-weight specifications available. The product profile features a narrow molecular-weight distribution, structural characterization and laboratory-verified activity.
| Form | Powder |
|---|---|
| Molecular-Weight | 3–5 kDa |
| Assay | ≥90.0% on a dried basis |
| MOQ | 1 kg |
| Packaging | 25 kg/drum |
As a manufacturer of Low Molecular Weight Chondroitin Sulfate Sodium, Ureda Naturals supplies a powder grade with a standard molecular-weight specification of 3–5 kDa and customized molecular-weight specifications for different formulation targets.
The product profile goes beyond a single molecular-weight figure. It features a narrow molecular-weight distribution, clear structural characterization and laboratory-verified activity. Compared with conventional chondroitin sulfate, the product is characterized by easier dissolution in water, easier digestion, absorption and utilization, reduced gastrointestinal irritation, and stronger anti-inflammatory, antioxidant and related biological activity.
Molecular weight may be expressed as a range, an average value or the proportion below a defined threshold. These descriptions are not interchangeable. When setting a purchase specification, identify the measurement format as well as the target value so that different grades can be compared on the same basis.
| Specification Option | Molecular-Weight Target | How to Interpret It |
|---|---|---|
| Standard low-molecular-weight grade | 3–5 kDa | Standard grade; the COA table below corresponds to this specification. |
| Customized molecular-weight range | <5 kDa | A range-based target. Confirm the measurement convention when defining the purchase specification. |
| Customized molecular-weight range | 5–15 kDa | A higher range option for projects requiring a different molecular-weight profile. |
| Distribution-defined grade | For example, ≥85% below 3 kDa | Specifies the fraction below a threshold; it is not the same as an average molecular weight of 3 kDa. |
| Ultra-low-molecular-weight chondroitin sulfate oligosaccharide | ≤1 kDa | A distinct ultra-low-molecular-weight option, separate from the standard 3–5 kDa grade. |
The following table presents the specification limits and COA results for the standard grade. Assay is calculated on the dried basis.
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White or almost white powder | Pass |
| Clarity (420 nm) | Absorbance ≤0.35 | 0.09 |
| Identification — liquid phase | Consistent with the retention time of the reference substance | Pass |
| Identification — IR spectrum | Consistent with the reference sample spectrum | Pass |
| Sodium salt reaction | Positive | Pass |
| pH value | 5.5–7.5 | 6.3 |
| Chloride | ≤0.5% | Pass |
| Sulfate radical | ≤0.24% | Pass |
| Protein (dry basis) | ≤3.0% | Pass |
| Loss on drying | ≤10.0% | 9.55% |
| Residue on ignition | 20.0–30.0% | 25.90% |
| Lead | ≤0.5 mg/kg | <0.04 mg/kg |
| Total arsenic | ≤0.1 mg/kg | <0.04 mg/kg |
| Total mercury | ≤0.1 mg/kg | <0.01 mg/kg |
| Total bacterial count | ≤1,000 CFU/g | Pass |
| Yeasts and molds | ≤100 CFU/g | Pass |
| Escherichia coli | Negative | Negative |
| Salmonella species | Negative | Negative |
| Staphylococcus aureus (/25 g) | Negative | Not detected (Negative) |
| Assay (calculated on the dried basis) | ≥90.0% | 96.80% |
Molecular-weight specification and assay answer different questions. Assay reports the measured chondroitin sulfate content, while molecular-weight data describes the size profile of the material. Two ingredients with similar assay values may still have different molecular-weight distributions. For grade selection, compare the molecular-weight definition and distribution alongside assay rather than treating assay as a substitute for molecular-weight data.
The COA reports assay on a dried basis and separately reports loss on drying. These values describe different properties: dried-basis assay expresses content after the specified drying calculation, while loss on drying measures mass loss under the test conditions. Keep the reporting basis consistent when comparing supplier specifications or setting a formulation target.
The COA reports a clarity absorbance of 0.09 at 420 nm against a limit of ≤0.35. For a clear beverage, first assess the ingredient in the intended aqueous phase, then repeat the observation after adding the complete formula and applying the planned process. Salts, proteins and hydrocolloids can change the appearance of a finished system, so staged trials help identify when a change occurs.
The COA specifies residue on ignition at 20.0–30.0%, with a result of 25.90%. This is a separate quality parameter; it should not be read as an organic-impurity percentage. Review it alongside assay, identification, chloride and sulfate results for a more complete quality assessment.
For solid dosage forms, the lower-molecular-weight profile and water solubility can support ingredient handling and dissolution planning. During development, evaluate powder flow, blend uniformity and dissolution in the actual excipient system. A water-solubility result alone does not establish how a powder blend will flow or perform in a finished dosage form.
For aqueous products, begin with the intended use level in the target water phase and record dissolution and appearance. Then add the complete beverage matrix and assess the product after processing and storage. This sequence helps distinguish initial dissolution behavior from changes introduced by the finished formula.
For cosmetic applications, assess dissolution, appearance and compatibility in the intended formula. The molecular-weight specification helps define the ingredient grade, while the finished formula determines its practical incorporation and final appearance.
Not necessarily. A 3–5 kDa specification is a stated molecular-weight range; it does not, by itself, define an average value or the percentage of material below a threshold. Confirm the measurement format and distribution data when comparing grades.
The product profile describes easier digestion, absorption and utilization, together with stronger related biological activity compared with conventional chondroitin sulfate. However, a lower molecular-weight number alone does not quantify those differences. Review the molecular-weight distribution, structural characterization and supporting activity data for the specific grade.
Not by percentage alone. First confirm that the results use the same reporting basis, such as dried basis, and review the assay method and specification definition. Then compare assay alongside molecular-weight profile and other relevant quality parameters.
Start by testing the ingredient at the intended use level in the target aqueous phase. Next, add the full formula, apply the planned processing conditions and check appearance during storage. Observing these stages separately helps identify whether a change begins during dissolution, after other ingredients are added, or during processing and storage.
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