{"id":1976,"date":"2026-10-15T13:34:54","date_gmt":"2026-10-15T05:34:54","guid":{"rendered":"https:\/\/uredanaturals.com\/?post_type=product&p=1976"},"modified":"2026-10-15T13:34:55","modified_gmt":"2026-10-15T05:34:55","slug":"epimedium-extract-icariin","status":"publish","type":"product","link":"https:\/\/uredanaturals.com\/es\/producto\/epimedium-extract-icariin\/","title":{"rendered":"Epimedium Extract (Icariin 98%)"},"content":{"rendered":"
Ureda Naturals manufactures Epimedium Extract standardized to not less than 98.0% Icariin by HPLC. The extract is produced from Epimedium brevicornu Maxim. leaves using water and ethanol extraction followed by purification.<\/p>\n

The high Icariin concentration reduces the amount of broader botanical matrix entering a formula but increases sensitivity to low-dose distribution, powder consolidation and process loss. Limited aqueous solubility also makes dosage-form selection and finished-product performance testing critical.<\/p>\n

\n

Product Profile<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
Product name<\/th>\nEpimedium Extract (Icariin 98%)<\/td>\n<\/tr>\n
Active compound<\/th>\nIcariin<\/td>\n<\/tr>\n
CAS number<\/th>\n489-32-7<\/td>\n<\/tr>\n
Molecular formula<\/th>\nC33<\/sub>H40<\/sub>O15<\/sub><\/td>\n<\/tr>\n
Molecular weight<\/th>\n676.66 g\/mol<\/td>\n<\/tr>\n
Botanical source<\/th>\nEpimedium brevicornu<\/em> Maxim.<\/td>\n<\/tr>\n
Plant part<\/th>\nLeaf<\/td>\n<\/tr>\n
Extraction solvents<\/th>\nWater and ethanol<\/td>\n<\/tr>\n
Assay<\/th>\n\u226598.0% Icariin by HPLC<\/td>\n<\/tr>\n
Appearance<\/th>\nBrown-yellow powder<\/td>\n<\/tr>\n
Particle size<\/th>\n100% through 80 mesh<\/td>\n<\/tr>\n
Identification<\/th>\nPositive by TLC<\/td>\n<\/tr>\n
Packaging<\/th>\n25 kg cardboard drum with double-layer inner bags<\/td>\n<\/tr>\n
Shelf life<\/th>\n24 months<\/td>\n<\/tr>\n
Storage<\/th>\nCool, dry and protected from strong light and heat<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
\n

Grade Identity<\/h2>\n\n\n\n\n\n\n\n\n\n
Material<\/th>\nDefining specification<\/th>\nTechnical distinction<\/th>\n<\/tr>\n<\/thead>\n
Epimedium Extract (Icariin 98%)<\/td>\nPurified Epimedium leaf extract standardized to \u226598.0% Icariin<\/td>\nProvides a defined, high-purity Icariin input<\/td>\n<\/tr>\n
Standardized Epimedium extract<\/td>\nBotanical extract adjusted to a lower declared Icariin level<\/td>\nIntroduces more accompanying botanical constituents<\/td>\n<\/tr>\n
Total Epimedium flavonoids<\/td>\nCombined flavonoid-group assay<\/td>\nThe reported percentage does not equal Icariin content<\/td>\n<\/tr>\n
Icariside II<\/td>\nDeglycosylated Icariin-related compound<\/td>\nDifferent identity and analytical response<\/td>\n<\/tr>\n
Icaritin<\/td>\nIcariin aglycone<\/td>\nDifferent physicochemical behavior<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Replacing a lower-assay standardized Epimedium extract with the 98% Icariin grade changes the constituent profile, ingredient mass and active-to-carrier ratio. Existing blend, recovery and stability data must therefore be revalidated.<\/p>\n<\/section>\n

\n

Application Fit<\/h2>\n\n\n\n\n\n\n\n\n\n\n
Finished-product format<\/th>\nTechnical assessment<\/th>\nCritical control<\/th>\n<\/tr>\n<\/thead>\n
Dry-filled capsules<\/td>\nSuitable after blend qualification<\/td>\nSegregation, feeding and dosage-unit uniformity<\/td>\n<\/tr>\n
Tablets<\/td>\nSuitable after process qualification<\/td>\nGranulation recovery, compression and dissolution<\/td>\n<\/tr>\n
Reconstituted sachets<\/td>\nSuitable for suspension-format products<\/td>\nWetting, sedimentation and delivered dose<\/td>\n<\/tr>\n
Suspension liquids<\/td>\nFeasible with an engineered vehicle<\/td>\nRheology, settling and filling uniformity<\/td>\n<\/tr>\n
Clear aqueous liquids<\/td>\nRequires a separate delivery system<\/td>\nDissolved fraction and precipitation control<\/td>\n<\/tr>\n
Gummies<\/td>\nRequires matrix-specific validation<\/td>\nHeat recovery, cooling behavior and unit uniformity<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
\n

Critical Manufacturing Controls<\/h2>\n

Low-Inclusion Blending<\/h3>\n

The high assay reduces the quantity of extract added to the production batch. A qualified premix is required when direct addition cannot produce acceptable Icariin uniformity.<\/p>\n

    \n
  • Define the carrier and active-to-carrier premix ratio.<\/li>\n
  • Control the addition sequence and blender fill level.<\/li>\n
  • Establish the mixing endpoint from multi-location assay results.<\/li>\n
  • Compare uniformity before discharge and after transfer.<\/li>\n
  • Test units from the beginning, middle and end of filling.<\/li>\n<\/ul>\n

    Increased assay variation after additional mixing or handling indicates re-segregation.<\/p>\n

    Density and Consolidation<\/h3>\n
      \n
    • Bulk density: 0.4521 g\/mL<\/li>\n
    • Tapped density: 0.5932 g\/mL<\/li>\n
    • Hausner ratio: approximately 1.31<\/li>\n
    • Carr index: approximately 23.8%<\/li>\n<\/ul>\n

      The measured consolidation can affect hopper discharge, volumetric feeding, capsule filling and separation from formulation components with different density. Production trials should reproduce expected vibration, hopper residence and transfer conditions.<\/p>\n

      Particle-Size Control<\/h3>\n

      The 80-mesh specification excludes coarse particles but does not define D10, D50, D90, fine-particle fraction, agglomeration or specific surface area.<\/p>\n

      Where particle behavior affects premixing, feeding, wetting, dissolution or suspension stability, purchasing limits should be established from full particle-size and application-performance data.<\/p>\n

      Process Recovery<\/h3>\n\n\n\n\n\n\n\n\n\n\n\n\n
      Sampling stage<\/th>\nPrimary failure identified<\/th>\n<\/tr>\n<\/thead>\n
      Dispensed material<\/td>\nWeighing or starting-potency error<\/td>\n<\/tr>\n
      Initial premix<\/td>\nIncomplete distribution or container retention<\/td>\n<\/tr>\n
      Multiple final-blender locations<\/td>\nBlend non-uniformity<\/td>\n<\/tr>\n
      Discharged blend<\/td>\nTransfer-induced segregation<\/td>\n<\/tr>\n
      Material at filling equipment<\/td>\nHopper or feeding instability<\/td>\n<\/tr>\n
      Beginning, middle and end of filling<\/td>\nProgressive segregation or settlement<\/td>\n<\/tr>\n
      Before and after filtration<\/td>\nInsoluble-particle or filter retention<\/td>\n<\/tr>\n
      Finished-product extraction<\/td>\nMatrix-related analytical recovery<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
      \n

      Dosage-Form Development<\/h2>\n

      Capsules<\/h3>\n

      Evaluate premix uniformity, segregation after transfer, hopper consolidation, fill-weight variation, dosage-unit Icariin content and dissolution. Capsule weight and Icariin content must be evaluated separately.<\/p>\n

      Tablets<\/h3>\n

      Evaluate recovery after granulation and drying, active migration during drying, uniformity after lubrication, assay after compression and finished-tablet dissolution. Hardness, friability and disintegration do not establish Icariin release.<\/p>\n

      Suspensions and Reconstituted Powders<\/h3>\n

      Measure wetting, agglomeration, sedimentation, sediment compactness, redispersibility, concentration during filling or consumption and the dose remaining in the preparation container.<\/p>\n

      Clear Aqueous Systems<\/h3>\n

      Establish equilibrium solubility, dissolved Icariin after validated phase separation, filtration recovery, dilution stability, temperature-cycle stability, pH and electrolyte effects, storage precipitation and filling-stage concentration.<\/p>\n

      Gummies<\/h3>\n

      Control the addition stage, maximum temperature, exposure time, post-heating recovery, distribution before depositing, cooling precipitation, individual-piece content and storage stability.<\/p>\n<\/section>\n

      \n

      Specification and COA<\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
      Test<\/th>\nSpecification<\/th>\nCOA result<\/th>\nMethod<\/th>\n<\/tr>\n<\/thead>\n
      Appearance<\/td>\nBrown-yellow powder<\/td>\nConforms<\/td>\nVisual<\/td>\n<\/tr>\n
      Icariin<\/td>\n\u226598.0%<\/td>\n98.21%<\/td>\nHPLC<\/td>\n<\/tr>\n
      Particle size<\/td>\n100% through 80 mesh<\/td>\nConforms<\/td>\nChP 2020<\/td>\n<\/tr>\n
      Identification<\/td>\nPositive<\/td>\nPositive<\/td>\nTLC<\/td>\n<\/tr>\n
      Moisture<\/td>\n\u22645.0%<\/td>\n3.59%<\/td>\nChP 2020<\/td>\n<\/tr>\n
      Total ash<\/td>\n\u22645.0%<\/td>\n1.87%<\/td>\nChP 2020<\/td>\n<\/tr>\n
      Bulk density<\/td>\nReport value<\/td>\n45.21 g\/100 mL<\/td>\nICH Q4B Annex 13<\/td>\n<\/tr>\n
      Tapped density<\/td>\nReport value<\/td>\n59.32 g\/100 mL<\/td>\nICH Q4B Annex 13<\/td>\n<\/tr>\n
      Total heavy metals<\/td>\n\u226410 ppm<\/td>\nConforms<\/td>\nChP 2020<\/td>\n<\/tr>\n
      Lead<\/td>\n\u22642.0 mg\/kg<\/td>\nConforms<\/td>\nGB 5009.12<\/td>\n<\/tr>\n
      Arsenic<\/td>\n\u22641.0 mg\/kg<\/td>\nConforms<\/td>\nGB 5009.11<\/td>\n<\/tr>\n
      Mercury<\/td>\n\u22640.3 mg\/kg<\/td>\nConforms<\/td>\nGB 5009.17<\/td>\n<\/tr>\n
      HCH<\/td>\n\u22640.2 mg\/kg<\/td>\nConforms<\/td>\nGB 5009.19<\/td>\n<\/tr>\n
      DDT<\/td>\n\u22640.2 mg\/kg<\/td>\nConforms<\/td>\nGB 5009.19<\/td>\n<\/tr>\n
      Total plate count<\/td>\n\u22641,000 CFU\/g<\/td>\nConforms<\/td>\nGB 4789.2<\/td>\n<\/tr>\n
      Yeast and mold<\/td>\n\u2264100 CFU\/g<\/td>\nConforms<\/td>\nGB 4789.15<\/td>\n<\/tr>\n
      Coliforms<\/td>\n\u226410 MPN\/100 g<\/td>\nConforms<\/td>\nGB 4789.3<\/td>\n<\/tr>\n
      Staphylococcus aureus<\/em><\/td>\nNegative<\/td>\nConforms<\/td>\nGB 4789.10<\/td>\n<\/tr>\n
      Salmonella<\/em><\/td>\nNegative<\/td>\nConforms<\/td>\nGB 4789.4<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
      \n

      Analytical and Source Qualification<\/h2>\n

      Source comparison should use the same Icariin reference standard, assigned standard potency, sample preparation, assay calculation and chromatographic method.<\/p>\n

        \n
      • Confirm Icariin peak identity and separation from adjacent peaks.<\/li>\n
      • Compare main-peak purity and non-main peak distribution.<\/li>\n
      • Evaluate replicate preparation precision.<\/li>\n
      • Compare particle size, density and manufacturing behavior.<\/li>\n
      • Confirm recovery in the intended process and finished-product matrix.<\/li>\n<\/ul>\n

        The finished-product method must demonstrate extraction recovery from the actual matrix before it is used to assess manufacturing loss.<\/p>\n<\/section>\n

        \n

        Selection Summary<\/h2>\n\n\n\n\n\n\n\n\n
        Select this grade when<\/th>\nSelect another format when<\/th>\n<\/tr>\n<\/thead>\n
        A defined high-purity Icariin input is required<\/td>\nA broad Epimedium botanical profile is required<\/td>\n<\/tr>\n
        Low botanical-matrix contribution is important<\/td>\nThe accompanying botanical matrix is part of the product concept<\/td>\n<\/tr>\n
        The product uses a qualified dry-dose process<\/td>\nDirect aqueous dispersibility is required<\/td>\n<\/tr>\n
        A dedicated delivery system can be developed<\/td>\nA ready-to-use soluble or dispersible system is required<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n
        \n

        Technical FAQ<\/h2>\n
        \nWhich attributes should be included in a quality agreement after pilot validation?<\/summary>\n

        Include only attributes shown to affect manufacturing or finished-product performance. These may include Icariin assay, specified related peaks, D10\/D50\/D90, density range, moisture and residual ethanol. Each added limit should be supported by blend, feeding, recovery, dissolution or stability data.<\/p>\n<\/details>\n

        \nWhich raw-material changes should trigger customer requalification?<\/summary>\n

        Requalification should be considered after changes to botanical species, plant part, extraction or purification process, manufacturing site, solvent system, HPLC method, reference standard, particle-size process or drying process. The comparison should address the risk introduced by the specific change.<\/p>\n<\/details>\n

        \nHow should a laboratory premix be transferred to commercial scale?<\/summary>\n

        Preserve or evaluate premix concentration, blender working volume, fill level, addition sequence, mixing intensity, discharge pattern, transfer distance and hopper residence. Commercial sampling must include discharged material and finished units.<\/p>\n<\/details>\n

        \nHow should colour variation be investigated when Icariin assay still complies?<\/summary>\n

        Compare botanical raw-material source, related-peak distribution, moisture, particle-size distribution, drying conditions and storage exposure. Use chromatographic and physical comparison to determine whether the difference originates from related constituents, processing history or particle characteristics.<\/p>\n<\/details>\n

        \nWhat evidence is required before approving an alternative source?<\/summary>\n

        Combine aligned-method identity and assay, chromatographic-profile comparison, physical-property comparison, contaminant compliance, pilot-process recovery, finished-product uniformity and dosage-form-specific performance data.<\/p>\n<\/details>\n<\/section>\n<\/article>","protected":false},"excerpt":{"rendered":"

        Ureda Naturals manufactures Epimedium Extract standardized to \u226598.0% Icariin by HPLC. Produced from Epimedium brevicornu Maxim. leaves, this high-purity grade is intended for capsules, tablets, suspension systems and engineered delivery formulations.<\/p>","protected":false},"featured_media":2000,"template":"","meta":[],"product_brand":[],"product_cat":[25],"product_tag":[210,208,209],"class_list":["post-1976","product","type-product","status-publish","has-post-thumbnail","product_cat-plant-extracts-botanical-ingredients","product_tag-epimedium-extract","product_tag-icariin","product_tag-icariin-98","first","instock","shipping-taxable","product-type-simple"],"yoast_head":"\nEpimedium Extract (Icariin 98%) Manufacturer | Ureda Naturals<\/title>\n<meta name=\"description\" content=\"Ureda Naturals manufactures Epimedium Extract standardized to \u226598% Icariin by HPLC for capsules, tablets and formulated delivery systems.\" \/>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta 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