Trans-Resveratrol

Ureda Naturals manufactures fermentation-derived Trans-Resveratrol in 99%, 50%, 20%, 10% water-soluble, granular and liposomal formats for nutraceutical, beverage, functional food and cosmetic applications.

Additional information

Product Name

Trans-Resveratrol

CAS

501-36-0

Source

Fermentation-derived

Form

Powder, Water-Soluble, Granular, Liposomal

Assay

99%, 50%, 20%, 10% Water-Soluble

MOQ

1 kg

Ureda Naturals is a Trans-Resveratrol manufacturer supplying fermentation-derived Trans-Resveratrol for nutraceutical, functional food, beverage, cosmetic and specialized delivery-system applications.

Available formats include 99% high-purity powder, 50% and 20% standardized grades, 10% water-soluble Trans-Resveratrol, granular Trans-Resveratrol and liposomal Trans-Resveratrol.

The correct specification depends on the finished-product dosage, processing method, powder-handling requirements, dispersion behavior and stability profile. Trans-Resveratrol should therefore be selected according to the final application rather than assay alone.

Product Identity and Supply Range

  • Product name: Trans-Resveratrol
  • CAS Number: 501-36-0
  • Molecular formula: C14H12O3
  • Molecular weight: 228.24 g/mol
  • Origin: Fermentation-derived
  • Available assay levels: 99%, 50%, 20% and 10% water-soluble
  • Available forms: Powder, water-soluble powder, granules and liposomal form
  • MOQ: 1 kg

Core Product Advantages

Ureda Naturals combines a fermentation-derived production route with controls for chemical purity, visual appearance, powder performance and application flexibility.

  • Fermentation-derived production using a GRAS-recognized production strain;
  • High-purity specifications with assay controlled at 99.0–101.0% on a dry basis;
  • Purity targets of ≥99.5% for selected high-purity specifications;
  • All-trans profile with cis-resveratrol and emodin not detected in the high-purity specification;
  • Ultra-white grade with a whiteness value above 90;
  • Controlled bulk density, tapped density and particle size;
  • Residual ethanol controlled at ≤1,000 ppm;
  • Control of pesticide residues and plasticizer residues;
  • Heavy-metal and microbiological testing;
  • C-14 documentation for origin assessment;
  • Powder, water-soluble, granular and liposomal formats for different formulation processes.

Production Route Comparison

Test Item Fermentation-Derived Trans-Resveratrol Chemically Synthesized Trans-Resveratrol Plant-Extracted Trans-Resveratrol
Appearance White or off-white powder Off-white or grayish-white powder Light yellow to brown powder
Odor Slight odor Pungent odor Pungent odor
Assay ≥99% ≥99% 50–98%
Maximum single impurity ≤0.10% ≤0.10% Multiple impurities at or above 0.10%
Total impurities ≤0.5% ≤0.5% Multiple impurity components may be present
Solvent residues Ethanol ≤1,000 ppm; no other solvent residues Ethanol ≤1,500 ppm; methanol ≤20 ppm Methanol ≤1,000 ppm; ethanol ≤1,500 ppm; other solvent residues may be present
Pesticide residues Not detected Pesticide residues not detected Pesticide residues such as BHC may be present
Plasticizer residues Not detected Plasticizer residues cannot be guaranteed absent Plasticizer residues may be present
Other potential impurities None identified in the stated comparison Process-related high-risk impurities may be present Emodin-related impurities, aflatoxins, polycyclic aromatic hydrocarbons and other undesirable substances may be present

Choose the Right Trans-Resveratrol Format

99% High-Purity Trans-Resveratrol Powder

The 99% Trans-Resveratrol powder is suitable for concentrated solid-dose products requiring a high active concentration with a relatively low raw-material input.

  • Capsules;
  • Tablets;
  • Powder sachets;
  • Dry premixes;
  • Nutraceutical blends;
  • High-purity cosmetic formulations.

The main process controls are assay, powder flow, bulk density, tapped density, particle-size distribution, blend uniformity and filling behavior.

50% and 20% Standardized Trans-Resveratrol

The 50% and 20% grades are useful when the finished formula requires a larger standardized input or a larger carrier matrix.

  • Standardized powder blends;
  • Stick packs and sachets;
  • Nutraceutical premixes;
  • Dry formulations requiring a larger dosing mass;
  • Products designed around a lower active concentration per unit mass.

The lower assay changes the total raw-material mass, carrier proportion, fill volume and mixing behavior.

10% Water-Soluble Trans-Resveratrol

The 10% water-soluble Trans-Resveratrol form is designed for functional beverages, oral liquids, powdered drink mixes, liquid nutritional products and water-based cosmetic systems.

High-purity Trans-Resveratrol powder has limited native water solubility. Short-term dispersion in water does not confirm suitability for a commercial beverage.

Aqueous development should evaluate initial dispersion, clarity or permitted turbidity, sedimentation, recrystallization, pH, ionic strength, mineral and protein interactions, homogenization, thermal treatment, holding time, light exposure, oxygen exposure, storage stability and final container compatibility.

Granular Trans-Resveratrol

Granular Trans-Resveratrol is suitable when fine-powder dust, feeding consistency or material transfer creates production challenges.

  • More consistent feeding;
  • Lower dust generation;
  • Easier material transfer;
  • Improved premix handling;
  • More stable dosing through production equipment.

Evaluation should include granule strength, moisture pickup, density, abrasion, breakage during blending and final dosage uniformity.

Liposomal Trans-Resveratrol

Liposomal Trans-Resveratrol is intended for lipid-based delivery systems rather than conventional crystalline powder formulations.

Its quality review should include active loading, particle-size distribution, encapsulation efficiency, leakage during storage, oxidative stability, homogenization conditions, filling temperature, light and oxygen protection and compatibility with the final container.

Liposomal Trans-Resveratrol should be evaluated as a complete delivery system rather than by assay alone.

How Assay Changes the Formula

For a nominal target of 100 mg Trans-Resveratrol:

  • 99% grade: approximately 101 mg of raw material;
  • 50% grade: approximately 200 mg of raw material;
  • 20% grade: approximately 500 mg of raw material;
  • 10% water-soluble grade: approximately 1,000 mg of raw material.

The final addition rate should be calculated using the assay shown on the current batch Trans-Resveratrol COA.

Assay affects capsule fill volume, tablet weight, sachet mass, carrier proportion, powder volume, beverage solids, cost per serving and finished-product content uniformity.

High-Purity Trans-Resveratrol Quality Specification

The following specification describes the high-purity powder format. Water-soluble, granular and liposomal formats are evaluated according to their corresponding product specifications.

Test Item Standard Grade Ultra-White Grade Test Method
Appearance Off-white powder White powder Visual
Moisture ≤0.5% ≤0.5% CP2020
Ash ≤0.5% ≤0.5% CP2020
Identification HPLC HPLC HPLC
Identification IR IR IR
Assay, on a dry basis 99.0–101.0% 99.0–101.0% HPLC
Bulk density ≥0.35 g/mL ≥0.40 g/mL USP <616>
Tapped density ≥0.70 g/mL ≥0.80 g/mL USP <616>
Cis-resveratrol Not detected Not detected HPLC
Emodin Not detected Not detected HPLC
Maximum single impurity ≤0.1% ≤0.1% HPLC
Total impurities ≤0.5% ≤0.5% HPLC
Purity ≥99.0% ≥99.0% HPLC
Residual ethanol ≤1,000 ppm ≤1,000 ppm GC
Total heavy metals ≤10 ppm ≤10 ppm CP2020
Lead ≤0.5 ppm ≤0.5 ppm ICP-MS
Cadmium ≤1.0 ppm ≤1.0 ppm ICP-MS
Arsenic ≤1.0 ppm ≤1.0 ppm ICP-MS
Mercury ≤0.1 ppm ≤0.1 ppm ICP-MS
Particle size 95% passing through 80 mesh 95% passing through 80 mesh Internal control
Total plate count ≤1,000 CFU/g ≤1,000 CFU/g CP2020
Total yeast and mold ≤1,000 CFU/g ≤1,000 CFU/g CP2020
Escherichia coli, coliforms and Pseudomonas aeruginosa Not detected Not detected CP2020
Salmonella Not detected Not detected CP2020
Storage Store sealed at room temperature and protect from light Store sealed at room temperature and protect from light —

Bulk density and tapped density affect capsule filling, hopper feeding, transport efficiency and the powder volume required for a defined dosage.

Particle size supports handling and dispersion control, but 80 mesh alone does not guarantee blend uniformity. Particle shape, density, electrostatic behavior, agglomeration and mixing conditions also affect the final blend.

Safety and Supporting Technical Data

The product quality profile includes controls for residual ethanol, heavy metals, pesticide residues, plasticizer residues, total plate count, yeast and mold, Escherichia coli, coliforms, Pseudomonas aeruginosa and Salmonella.

Supporting third-party reports can be provided for heavy metals, pesticide residues and microbiological quality.

The technical material reports an acute oral LD50 above 5,000 mg/kg in ICR mice and classifies the tested material as practically non-toxic under the stated acute-toxicity classification.

Match Trans-Resveratrol to the Finished-Product Process

Capsules, Tablets and Dry Blends

For solid dosage forms, the key development factors are assay, powder flow, density, blend uniformity, segregation, compression and fill volume.

The 99% grade reduces the raw-material mass required for a given active dose. The 50% and 20% grades provide a larger standardized input. Granules may be selected when dust control and feeding consistency are important.

Functional Beverages and Oral Liquids

For water-based products, the 10% water-soluble Trans-Resveratrol form is the preferred starting point.

Evaluation should include appearance immediately after mixing, sedimentation during storage, recrystallization, pH stability, mineral and protein interactions, homogenization, heat treatment, holding time, light and oxygen exposure and storage stability.

High-purity powder should not be substituted into a beverage formula without reviewing its dispersion and storage behavior.

Cosmetic Serums, Gels and Creams

Cosmetic formulations should control final pH, heat exposure, oxygen exposure, light exposure, addition sequence, vehicle compatibility, dispersion, color change, precipitation, container opacity and storage stability.

Light-protective packaging may be selected when the finished product is sensitive to light exposure.

Granular and Liposomal Systems

Granular Trans-Resveratrol should be evaluated for particle strength, feeding behavior, dust generation, breakage, moisture pickup and dosage uniformity.

Liposomal Trans-Resveratrol should be evaluated for active loading, particle size, encapsulation efficiency, leakage, oxidation, homogenization and storage stability.

Fermentation Origin and C-14 Documentation

Fermentation-derived Trans-Resveratrol provides a defined production route for customers who require a biobased origin profile.

A C-14 report supports origin assessment and should be reviewed together with HPLC identity and assay, IR identification, related-substance profile, residual solvent testing, heavy-metal testing and microbiological testing.

C-14 documentation supports origin assessment and complements the identity, assay and impurity information shown in the product specification and batch COA.

Bulk Trans-Resveratrol Packaging and Storage

Available packaging options include:

  • 1 kg bag;
  • 5 kg bag;
  • 10 kg bag;
  • 5 kg paper drum;
  • 10 kg paper drum;
  • 25 kg paper drum.

Bag packaging uses an inner PE bag with an outer aluminum foil layer. Drum packaging uses a sealed inner liner with an outer paper drum.

powder packed in 10 kg, 5 kg and 1 kg bags

Quality and Certification Documentation

Available documentation and quality references for the selected Trans-Resveratrol specification include:

  • Batch COA;
  • Product specification;
  • TDS;
  • SDS;
  • C-14 report;
  • Heavy-metal report;
  • Pesticide-residue report;
  • Microbiological report;
  • GMP documentation;
  • NSF-related documentation;
  • ISO 9001 documentation;
  • HACCP documentation;
  • FSSC 22000 documentation;
  • BRCGS-related documentation;
  • Halal documentation;
  • Kosher documentation;
  • SGS third-party testing reports;
  • FDA-related regulatory support documents;
  • GRAS self-affirmed supporting documentation.

Ureda Naturals quality and compliance banner for bulk nutraceutical ingredient supply

Frequently Asked Questions

Why is the Trans-Resveratrol format more important than assay alone?

Assay determines active concentration, but the physical form determines dispersion, flow, filling, mixing and stability behavior. A 99% powder, a 10% water-soluble grade, a granule and a liposomal system require different process controls.

How do 99%, 50%, 20% and 10% grades change the formula?

They change the raw-material quantity required to deliver the same active dose. This affects fill weight, carrier level, capsule capacity, powder volume, beverage solids and finished-product uniformity.

Why may 99% Trans-Resveratrol powder be unsuitable for a beverage?

High-purity powder has limited native water solubility. It may initially disperse but later produce haze, sediment or recrystallization. The 10% water-soluble form is a more suitable starting point for beverage development.

Why does passing 80 mesh not guarantee blend uniformity?

Mesh size only describes sieve passage. Particle shape, density, electrostatic behavior, agglomeration, transfer distance and mixing conditions also affect uniformity.

Why should cis-resveratrol, emodin and total impurities be reviewed separately?

Assay confirms the amount of Trans-Resveratrol, while related-substance testing describes the composition of the remaining material. Reviewing both provides a more complete assessment of chemical consistency.

Does an ultra-white appearance prove higher chemical purity?

No. Ultra-white appearance is valuable when the finished product requires a lighter color, but appearance does not replace HPLC assay, identity testing or impurity testing.

What changes when liposomal Trans-Resveratrol is selected?

The quality review expands beyond assay and purity. Active loading, particle size, encapsulation efficiency, leakage, oxidation and storage stability become important performance parameters.

How should cosmetic formulations protect Trans-Resveratrol?

Control pH, heat, oxygen, light and addition sequence. The final container should also reduce exposure to conditions that may cause color change, precipitation or active degradation.

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